Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids (Review)

被引:88
作者
Cheng, ZJ [1 ]
Singh, RD [1 ]
Marks, DL [1 ]
Pagano, RE [1 ]
机构
[1] Mayo Clin & Mayo Fdn, Thorac Dis Res Unit, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
关键词
lactosylceramide; gangliosides; rho proteins;
D O I
10.1080/09687860500460041
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Caveolae are flask-shape membrane invaginations of the plasma membrane that have been implicated in endocytosis, transcytosis, and cell signaling. Recent years have witnessed the resurgence of studies on caveolae because they have been found to be involved in the uptake of some membrane components such as glycosphingolipids and integrins, as well as viruses, bacteria, and bacterial toxins. Accumulating evidence shows that endocytosis mediated by caveolae requires unique structural and signaling machinery (caveolin-1, src kinase), which indicates that caveolar endocytosis occurs through a mechanism which is distinct from other forms of lipid microdomain-associated, clathrin-independent endocytosis. Furthermore, a balance of glycosphingolipids, cholesterol, and caveolin-1 has been shown to be important in regulating caveolae endocytosis.
引用
收藏
页码:101 / 110
页数:10
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