Ablation of Proliferating Cells in the CNS Exacerbates Motor Neuron Disease Caused by Mutant Superoxide Dismutase

被引：17

作者：

Audet, Jean-Nicolas ^{[1
]}

Gowing, Genevieve ^{[1
]}

Paradis, Renee ^{[1
]}

Soucy, Genevieve ^{[1
]}

Julien, Jean-Pierre ^{[1
]}

机构：

[1] Univ Laval, CHUQ, Res Ctr, Dept Psychiat & Neurosci, Quebec City, PQ, Canada

来源：

PLOS ONE | 2012年 / 7卷 / 04期

关键词：

GROWTH-FACTOR-I; MOUSE MODEL; EXTEND SURVIVAL; ANIMAL-MODEL; SPINAL-CORD; MICROGLIA; IGF-1; PROGRESSION; ASTROCYTES; SOD1;

D O I：

10.1371/journal.pone.0034932

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Proliferation of glia and immune cells is a common pathological feature of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (ICV) with the anti-mitotic drug cytosine arabinoside (Ara-C). ICV delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS. Ara-C treatment caused substantial decreases in the number of microglia, NG2+ progenitors, Olig2+ cells and CD3+ T cells in the lumbar spinal cord of symptomatic SOD1(G93A) transgenic mice. Exacerbation of disease was also associated with significant alterations in the expression inflammatory molecules IL-1 beta, IL-6, TGF-beta and the growth factor IGF-1.

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页数：7

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