Proliferation of glia and immune cells is a common pathological feature of many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Here, to investigate the role of proliferating cells in motor neuron disease, SOD1(G93A) transgenic mice were treated intracerebroventicularly (ICV) with the anti-mitotic drug cytosine arabinoside (Ara-C). ICV delivery of Ara-C accelerated disease progression in SOD1(G93A) mouse model of ALS. Ara-C treatment caused substantial decreases in the number of microglia, NG2+ progenitors, Olig2+ cells and CD3+ T cells in the lumbar spinal cord of symptomatic SOD1(G93A) transgenic mice. Exacerbation of disease was also associated with significant alterations in the expression inflammatory molecules IL-1 beta, IL-6, TGF-beta and the growth factor IGF-1.
机构:
RIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, JapanRIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, Japan
Lasiene, Jurate
;
Yamanaka, Koji
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机构:
RIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, Japan
Japan Sci & Technol Agcy, CREST, Tokyo 1020075, Japan
Kyoto Univ, Grad Sch Med, Dept State of the Art & Int Med, Kyoto 6068501, JapanRIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, Japan
机构:
RIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, JapanRIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, Japan
Lasiene, Jurate
;
Yamanaka, Koji
论文数: 0引用数: 0
h-index: 0
机构:
RIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, Japan
Japan Sci & Technol Agcy, CREST, Tokyo 1020075, Japan
Kyoto Univ, Grad Sch Med, Dept State of the Art & Int Med, Kyoto 6068501, JapanRIKEN Brain Sci Inst, Lab Motor Neuron Dis, 2-1 Hirosawa, Saitama 3510198, Japan