Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus)

被引：102

作者：

Ferris, CF ^{[1
]}

Stolberg, T ^{[1
]}

Delville, Y ^{[1
]}

机构：

[1] Univ Massachusetts, Med Ctr, Dept Psychiat, Neuropsychiat Sci Program, Worcester, MA 01655 USA

来源：

BEHAVIORAL NEUROSCIENCE | 1999年 / 113卷 / 04期

关键词：

D O I：

10.1037/0735-7044.113.4.804

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

These studies examined the neurochemistry and neuroanatomy of the serotonin (5-HT) system innervating the anterior hypothalamus (AH) and the interaction of 5-HT receptor agonists with arginine vasopressin (AVP) in the regulation of offensive aggression in golden hamsters. Because specific 5-HT1A, 5-HT1B, and AVP V-1A binding sites were observed within the AH by in vitro autoradiography, the hamsters were tested for offensive aggression after microinjections of AVP in combination with either the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetraline (DPAT) or the 5-HT1B agonist CGS-12066A (CGS) directly within the AH. Though treatment with DPAT resulted in a dose-dependent inhibition of AVP-facilitated offensive aggression, CGS was ineffective. In addition, a retrograde tracer was injected within the AH to localize the distribution of 5-HT neurons projecting to the area. Retrogradely labeled 5-HT neurons were found within the dorsal, median, and caudal linear raphe nuclei and are suspected to inhibit AVP-facilitated offensive aggression by an activation of 5-HT1A receptors in the AH.

引用

页码：804 / 815

页数：12

共 72 条

[11] LIGHT AND ELECTRON-MICROSCOPIC ANALYSIS OF PROJECTION NEURONS RETROGRADELY LABELED WITH FLUOROGOLD - NOTES ON THE APPLICATION OF ANTIBODIES TO FLUOROGOLD [J].

CHANG, HT ;

KUO, H ;

WHITTAKER, JA ;

COOPER, NGF .

JOURNAL OF NEUROSCIENCE METHODS, 1990, 35 (01) :31-37

[12] Cerebrospinal fluid vasopressin levels -: Correlates with aggression and serotonin function in personality-disordered subjects [J].

Coccaro, EF ;

Kavoussi, RJ ;

Hauger, RL ;

Cooper, TB ;

Ferris, CF .

ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (08) :708-714

[13]

Coccaro EF, 1997, ARCH GEN PSYCHIAT, V54, P1081

[14] Serotonin agonist-induced decreases in intermale aggression are dependent on brain region and receptor subtype [J].

CologerClifford, A ;

Simon, NG ;

Lu, SF ;

Smoluk, SA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1997, 58 (02) :425-430

[15]

COLOGERCLIFFORD A, IN PRESS PHYSL BEHAV

[16]

DALTA KP, 1991, INDIAN J EXPT BIOL, V29, P631

[17] 8-OH-DPAT in the median raphe, dorsal periaqueductal gray and corticomedial amygdala nucleus decreases, but in the medial septal area it can increase maternal aggressive behavior in rats [J].

De Almeida, RMM ;

Lucion, AB .

PSYCHOPHARMACOLOGY, 1997, 134 (04) :392-400

[18]

Deckel AW, 1996, BEHAV BRAIN RES, V78, P175

[19] Testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus [J].

Delville, W ;

Mansour, KM ;

Ferris, CF .

PHYSIOLOGY & BEHAVIOR, 1996, 60 (01) :25-29

[20] Serotonin blocks vasopressin-facilitated offensive aggression: Interactions within the ventrolateral hypothalamus of golden hamsters [J].

Delville, Y ;

Mansour, KM ;

Ferris, CF .

PHYSIOLOGY & BEHAVIOR, 1996, 59 (4-5) :813-816

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