Cleavage of the nuclear matrix protein NuMA during apoptosis

被引：49

作者：

GuethHallonet, C ^{[1
]}

Weber, K ^{[1
]}

Osborn, M ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,DEPT BIOCHEM,D-37070 GOTTINGEN,GERMANY

来源：

EXPERIMENTAL CELL RESEARCH | 1997年 / 233卷 / 01期

关键词：

D O I：

10.1006/excr.1997.3557

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NuMA is a component of the nuclear matrix which may play a structural role in the architecture of the interphase nucleus. During apoptosis NuMA is redistributed within the nucleus and is proteolysed hom a 238-kDa form to a 180- to 200-kDa form. Here we show that the cleavage site leading to the stable fragment occurs between residues 1701 and 1725. Both the changes in morphology associated with apoptosis and the cleavage of NuMA were retarded by treatment with TPCK but not by treatment by other protease inhibitors including ICE inhibitor II. (C) 1997 Academic Press.

引用

页码：21 / 24

页数：4

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