Synthesis of 4-(3-hydroxyalkyl)pyrimidines by ring transformation reactions of 2-alkylidenetetrahydrofurans with amidines

被引：25

作者：

Bellur, Esen

Langer, Peter

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Inst Chem & Biochem, D-17487 Greifswald, Germany

[3] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

TETRAHEDRON | 2006年 / 62卷 / 23期

关键词：

Amidines; heterocycles; pyrimidines; ring transformation; tetrahydrofurans;

D O I：

10.1016/j.tet.2006.03.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Domino reactions of amidines with 2-alkylidenetetrahydrofurans, prepared by cyclization of 1,3-dicarbonyl dianions or 1,3-bissilyl enol ethers with various dielectrophiles, provided an efficient access to 4-(3-hydroxyalkyl)pyrimidines. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5426 / 5434

页数：9

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