Evidence for developmental changes in the visual word processing network beyond adolescence

被引:172
作者
Brem, S
Bucher, K
Halder, P
Summers, P
Dietrich, T
Martin, E
Brandeis, D
机构
[1] Univ Zurich, Dept Child & Adolescent Psychiat, CH-8032 Zurich, Switzerland
[2] Univ Zurich, Childrens Hosp, MR Ctr, CH-8006 Zurich, Switzerland
[3] Univ Zurich Hosp, Inst Neuroradiol, CH-8091 Zurich, Switzerland
关键词
D O I
10.1016/j.neuroimage.2005.09.023
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Late development of specialization in the visual word processing system was examined using event-related potentials (ERP) and functional magnetic resonance imaging (fMRI) of word and symbol string processing in groups of adolescents (15.2-17.3 years) and adults (19.8-30.8 years). We focused our ERP analyses on fast visual activity: the occipital P1 (82-131 ms) modulated by physical stimulus characteristics and the occipito-temporal N1 (132-256 ms) reflecting visual tuning for print. Our fMRI analyses concentrated on basal occipito-temporal activations in the visual word form area VWFA. For words, the correlation of fMRI activation in the VWFA and N1 amplitude confirmed the close relationship of the electrophysioiogical N1 with metabolic activity in the VWFA. Further support for this relationship came from low resolution electromagnetic tomography localizing the word-specific N1 near the VWFA. Both imaging techniques revealed age-independent differences between words and symbol strings. Late development, however, was preferentially detected with ERPs. Decreases of P1 and N1 amplitudes with age were not limited to words and suggested further maturation of the underlying brain microstructure and function. Following adolescence, decreasing N1 latencies specific to words point to continued specialization of the visual word processing system. Both N1 and fMRI measures correlated with reading performance. In summary' the similarity of global fMRI activation patterns between groups suggests a fully established distribution of the reading network in adolescence, while the decreasing N1 latencies for words indicate protracted fine tuning after adolescence. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:822 / 837
页数:16
相关论文
共 94 条
  • [1] HUMAN EXTRASTRIATE VISUAL-CORTEX AND THE PERCEPTION OF FACES, WORDS, NUMBERS, AND COLORS
    ALLISON, T
    MCCARTHY, G
    NOBRE, A
    PUCE, A
    BELGER, A
    [J]. CEREBRAL CORTEX, 1994, 4 (05) : 544 - 554
  • [2] Visual categorization during childhood: An ERP study
    Batty, M
    Taylor, MJ
    [J]. PSYCHOPHYSIOLOGY, 2002, 39 (04) : 482 - 490
  • [3] Working memory(s)
    Becker, JT
    Morris, RG
    [J]. BRAIN AND COGNITION, 1999, 41 (01) : 1 - 8
  • [4] ERP manifestations of processing printed words at different psycholinguistic levels: Time course and scalp distribution
    Bentin, S
    Mouchetant-Rostaing, Y
    Giard, MH
    Echallier, JF
    Pernier, J
    [J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 1999, 11 (03) : 235 - 260
  • [5] The development of specialized brain systems in reading and oral-language
    Booth, JR
    Burman, DD
    Van Santen, FW
    Harasaki, Y
    Gitelman, DR
    Parrish, TB
    Mesulam, MM
    [J]. CHILD NEUROPSYCHOLOGY, 2001, 7 (03) : 119 - 141
  • [6] SCOPOLAMINE EFFECTS ON VISUAL INFORMATION-PROCESSING, ATTENTION, AND EVENT-RELATED POTENTIAL MAP LATENCIES
    BRANDEIS, D
    NAYLOR, H
    HALLIDAY, R
    CALLAWAY, E
    YANO, L
    [J]. PSYCHOPHYSIOLOGY, 1992, 29 (03) : 315 - 336
  • [7] BRANDSMA JW, 1995, J REHABILITATION SCI, V8, P2
  • [8] Neurophysiological signs of rapidly emerging visual expertise for symbol strings
    Brem, S
    Lang-Dullenkopf, A
    Maurer, U
    Halder, P
    Bucher, K
    Brandeis, D
    [J]. NEUROREPORT, 2005, 16 (01) : 45 - 48
  • [9] Brett M, 2002, REGION INTEREST ANAL
  • [10] Developmental changes in human cerebral functional organization for word generation
    Brown, TT
    Lugar, HM
    Coalson, RS
    Miezin, FM
    Petersen, SE
    Schlaggar, BL
    [J]. CEREBRAL CORTEX, 2005, 15 (03) : 275 - 290