The interaction of proteins with solid surfaces

被引:668
作者
Gray, JJ [1 ]
机构
[1] Johns Hopkins Univ, Baltimore, MD 21218 USA
关键词
D O I
10.1016/j.sbi.2003.12.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The interaction of proteins with solid surfaces is a fundamental phenomenon with implications for nanotechnology, biomaterials and biotechnological processes. Kinetic and thermodynamic studies have long indicated that significant conformational changes may occur as a protein encounters a surface; new techniques are measuring and modeling these changes. Combinatorial and directed evolution techniques have created new peptide sequences that bind specifically to solid surfaces, similar to the natural proteins that regulate crystal growth. Modeling efforts capture kinetics and thermodynamics on the colloidal scale, but detailed treatments of atomic structure are still in development and face the usual challenges of protein modeling. Opportunities abound for fundamental discovery, as well as breakthroughs in biomaterials, biotechnology and nanotechnology.
引用
收藏
页码:110 / 115
页数:6
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