Polymer gene delivery: overcoming the obstacles

被引：146

作者：

Aied, Ahmed ^{[1
]}

Greiser, Udo ^{[1
]}

Pandit, Abhay ^{[1
]}

Wang, Wenxin ^{[1
]}

机构：

[1] Natl Univ Ireland, Network Excellence Funct Biomat, Galway, Ireland

来源：

DRUG DISCOVERY TODAY | 2013年 / 18卷 / 21-22期

关键词：

IN-VIVO DISTRIBUTION; BLOCK-COPOLYMER; TRANSFECTION EFFICIENCY; NONVIRAL VECTOR; DNA DELIVERY; POLYETHYLENIMINE; POLYPLEXES; EXPRESSION; COMPLEXES; COMBINATORIAL;

D O I：

10.1016/j.drudis.2013.06.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent progress in gene therapy has opened doors for the development of new and multifunctional delivery agents based on the tailored synthesis of polymers. These polymers are in their infancy compared with viral agents, which have been optimised during millions of years of evolution, making viral vectors naturally efficient transfection agents. To improve the efficiency of polymer gene delivery to the level seen in viral vectors, it is necessary to understand the challenges faced by polymer gene delivery vectors both in vitro and in vivo. In this review, we analyse and discuss those obstacles that scientists have to overcome to design a highly efficient synthetic transfection agent.

引用

页码：1090 / 1098

页数：9

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