The design of scaffolds for use in tissue engineering. Part 1. Traditional factors

被引:1678
作者
Yang, SF [1 ]
Leong, KF [1 ]
Du, ZH [1 ]
Chua, CK [1 ]
机构
[1] Nanyang Technol Univ, Sch Mech & Prod Engn, Ctr Design Res, Singapore 639798, Singapore
来源
TISSUE ENGINEERING | 2001年 / 7卷 / 06期
关键词
D O I
10.1089/107632701753337645
中图分类号
Q813 [细胞工程];
学科分类号
摘要
In tissue engineering, a highly porous artificial extracellular matrix or scaffold is required to accommodate mammalian cells and guide their growth and tissue regeneration in three dimensions. However, existing three-dimensional scaffolds for tissue engineering proved less than ideal for actual applications, not only because they lack mechanical strength, but they also do not guarantee interconnected channels. In this paper, the authors analyze the factors necessary to enhance the design and manufacture of scaffolds for use in tissue engineering in terms of materials, structure, and mechanical properties and review the traditional scaffold fabrication methods. Advantages and limitations of these traditional methods are also discussed.
引用
收藏
页码:679 / 689
页数:11
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