Application of automation and thermal analysis to resolving agent selection

被引：18

作者：

Dyer, UC ^{[1
]}

Henderson, DA ^{[1
]}

Mitchell, MB ^{[1
]}

机构：

[1] Roche Discovery Welwyn, Chem Synth Dept, Welwyn Garden City AL7 3AY, Herts, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1999年 / 3卷 / 03期

关键词：

D O I：

10.1021/op9800818

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The use of differential scanning calorimetry as a means to identify diastereoisomeric salts with a clear eutectic composition that is needed for effective resolution is described and forms the basis of a resolving agent screening process. Automated salt synthesis using an Advanced ChemTech robot is also described. Rapid data analysis is facilitated using an in-house software package, Resolution Companion, which also enables identification of the optimum crystallization conditions following a trial crystallization experiment.

引用

页码：161 / 165

页数：5

共 6 条

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Bruggink, A
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[J]. TETRAHEDRON-ASYMMETRY, 1997, 8 (24) : 4047 - 4057
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