New resolving bases for ibuprofen and mandelic acid: qualification by binary phase diagrams

被引：36

作者：

Ebbers, EJ

Plum, BJM

Ariaans, GJA

Kaptein, B

Broxterman, QB

Bruggink, A

Zwanenburg, B

机构：

[1] Catholic Univ Nijmegen, Dept Organ Chem, NSR, Ctr Mol Struct Design & Synth, NL-6525 ED Nijmegen, Netherlands

[2] DSM Res BV, Organ Chem & Biotechnol Sect, NL-6160 MD Geleen, Netherlands

[3] Chemferm, NL-4800 DX Breda, Netherlands

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(97)00557-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New resolving bases for ibuprofen 1 and mandelic acid 2 were studied and qualified by their binary phase diagrams of the corresponding salts. It was shown that analysis of the binary phase diagrams gives a good prediction for a resolution process. A comparison of resolving bases revealed that (S)-phenylglycinol (S)-7 is the best resolving base for ibuprofen 1. By the same procedure, various resolving bases for mandelic acid 2 were studied. The known resolving base (S)-MBA 9 was found to be the best for this acid. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：4047 / 4057

页数：11

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