Sirtuins - novel therapeutic targets to treat age-associated diseases

被引：378

作者：

Lavu, Siva ^{[1
]}

Boss, Olivier ^{[1
]}

Elliott, Peter J. ^{[1
]}

Lambert, Philip D. ^{[1
]}

机构：

[1] Sirtris Pharmaceut GSK Co, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2008年 / 7卷 / 10期

关键词：

D O I：

10.1038/nrd2665

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sirtuins post-translationally modulate the function of many cellular proteins that undergo reversible acetylation-deacetylation cycles, affecting physiological responses that have implications for treating diseases of ageing. Potent small-molecule modulators of sirtuins have shown efficacy in preclinical models of metabolic, neurodegenerative and inflammatory diseases, and so hold promise for drug discovery efforts in multiple therapeutic areas. Here, we discuss current knowledge and data that strengthens sirtuins as a druggable set of enzymes for the treatment of age-associated diseases, including activation of SIRT1 in type 2 diabetes.

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页码：841 / 853

页数：13

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