Poly(ethylene)glycol/AlCl3 as a new and efficient system for multicomponent Biginelli-type synthesis of pyrimidinone derivatives

被引：16

作者：

Amoozadeh, Ali ^{[1
]}

Rahmani, Salman ^{[1
]}

Nemati, Firouzeh ^{[1
]}

机构：

[1] Semnan Univ, Dept Organ Chem, Fac Chem, Semnan 35195363, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2013年 / 19卷 / 01期

关键词：

aluminum chloride; Biginelli condensation; poly(ethylene)glycol; pyrimidinone; ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; IMPROVED PROTOCOL CONDITIONS; CALCIUM-CHANNEL BLOCKERS; CONDENSATION REACTION; ACID-ESTERS; DIHYDROPYRIMIDINONES; GREEN; CATALYST; ALDEHYDES;

D O I：

10.1515/hc-2012-0157

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

Biginelli condensation of aldehydes, cyclopentanone and urea or thiourea in poly(ethylene)glycol 400, at 45 degrees C in the presence of aluminum chloride as a highly efficient catalyst has been developed. The reaction is very fast, clean and environmentally benign for the synthesis of a vast variety of pyrimidinone derivatives.

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收藏

页码：69 / 73

页数：5

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