Cross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2

被引：99

作者：

Acunzo, Mario ^{[1
]}

Romano, Giulia ^{[1
]}

Palmieri, Dario ^{[1
]}

Lagana, Alessandro ^{[1
]}

Garofalo, Michela ^{[1
]}

Balatti, Veronica ^{[1
]}

Drusco, Alessandra ^{[1
]}

Chiariello, Mario ^{[2
,3
]}

Nana-Sinkam, Patrick ^{[4
]}

Croce, Carlo M. ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[2] Ist Toscano Tumori Core Res Lab, I-53100 Siena, Italy

[3] Consiglio Nazl Ric IFC, I-53100 Siena, Italy

[4] Ohio State Univ, Wexner Med Ctr, Dorothy M Davis Heart & Lung Res Inst, Div Pulm Allergy Crit Care & Sleep Med, Columbus, OH 43210 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 21期

基金：

美国国家卫生研究院;

关键词：

cell signaling; epigenetics; GROWTH-FACTOR RECEPTOR; C-MET; MIR-23A-SIMILAR-TO-27A-SIMILAR-TO-24-2; CLUSTER; UP-REGULATION; EXPRESSION; RESISTANCE; APOPTOSIS; PROTEIN; ACTIVATION; INHIBITION;

D O I：

10.1073/pnas.1302107110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the past decade, we have observed exciting advances in lung cancer therapy, including the development of targeted therapies. However, additional strategies for early detection and tumor-based therapy are still essential in improving patient outcomes. EGF receptor (EGFR) and MET (the receptor tyrosine kinase for hepatocyte growth factors) are cell-surface tyrosine kinase receptors that have been implicated in diverse cellular processes and as regulators of several microRNAs (miRNAs), thus contributing to tumor progression. Here, we demonstrate a biological link between EGFR, MET, and the miRNA cluster 23a similar to 27a similar to 24-2. We show that miR-27a regulates MET, EGFR, and Sprouty2 in lung cancer. In addition, we identify both direct and indirect mechanisms by which miR-27a can regulate both MET and EGFR. Thus, we propose a mechanism for MET and EGFR axis regulation that may lead to the development of therapeutics in lung cancer.

引用

页码：8573 / 8578

页数：6

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