Short report:: Responses to Leishmania donovani in mice deficient in both phagocyte oxidase and inducible nitric oxide synthase

被引：30

作者：

Murray, HW

Xiang, ZY

Ma, XJ

机构：

[1] Cornell Univ, Dept Med, Weill Med Coll, New York, NY 10021 USA

[2] Cornell Univ, Dept Microbiol & Immunol, Weill Med Coll, New York, NY 10021 USA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 74卷 / 06期

关键词：

D O I：

10.4269/ajtmh.2006.74.1013

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained Leishmania donovani visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by L. donovani, emerges after chemotherapy.

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收藏

页码：1013 / 1015

页数：3

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