Stabilization of the DNA I-motif structure by incorporation of 3′-S-phosphorothiolate linkages

被引：35

作者：

Brazier, JA

Fisher, J ^{[1
]}

Cosstick, R

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 01期

关键词：

DNA structures; i-motif; NMR spectroscopy; nucleic acids; phosphorothiolates;

D O I：

10.1002/anie.200503110

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A stable i: The i-motif is a unique, four-stranded DNA structure associated with cytosine-rich sequences at the ends of human chromosomes. This is the first report of an i-motif stabilized by a deoxy-cytidine analogue and demonstrates the importance of the sugar conformation in the i-motif structure. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：114 / 117

页数：4

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