Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA:RNA hybrid;: implications for antisense drug design

被引：17

作者：

Beevers, APG

Fettes, KJ

O'Neil, IA

Roberts, SM

Arnold, JRP

Cosstick, R

Fisher, J ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[3] Univ Bradford, YCR Lab Drug Design, Bradford BD7 1DP, W Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 14期

关键词：

D O I：

10.1039/b203582k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effects of a single 3'-S-phosphorothiolate link in the DNA strand of a DNA: RNA dodecamer duplex is described; the sulfur induces a conformational shift in the (attached) sugar pucker, as shown by H-1 NMR studies, and increases the thermal stability of the duplex compared to the nonmodified system.

引用

页码：1458 / 1459

页数：2

共 37 条

[1] Antisense therapeutics: is it as simple as complementary base recognition? [J].