Antisense therapeutics: is it as simple as complementary base recognition?

被引：132

作者：

Agrawal, S ^{[1
]}

Kandimalla, ER ^{[1
]}

机构：

[1] Hybridon, Discovery, Milford, MA 01757 USA

来源：

MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1357-4310(99)01638-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antisense oligonucleotides provide a simple and efficient approach for developing target-selective drugs because they can modulate gene expression sequence-specifically. Antisense oligonucleotides have also become efficient molecular biological tools to investigate the function of any protein in the cell. As the application of antisense oligonucleotides has expanded, multiple mechanisms of oligonucleotides have been characterized that impede their routine use. Here, we discuss different mechanisms of action of oligonucleotides and the possible ways of minimizing antisense-related effects to improve their specificity.

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页码：72 / 81

页数：10

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