Mixed-backbone oligonucleotides containing phosphorothioate and methylphosphonate linkages as second generation antisense oligonucleotide

被引：7

作者：

Agrawal, S

Jiang, ZW

Zhao, QY

Shaw, D

Sun, D

Saxinger, C

机构：

[1] UNIV ALABAMA,LURLEEN B WALLACE TUMOR INST,BIRMINGHAM,AL 35233

[2] NCI,DIV BASIC SCI,BETHESDA,MD 20892

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期

关键词：

D O I：

10.1080/07328319708006109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antisense oligonucleotides are being studied as novel therapeutic agents. To further improve the properties of antisense oligonucleotides, we have synthesized phosphorothioate oligonucleotides containing methylphosphonate linkages at the 5'-end, the 3'-end, or in the center, and have evaluated the impact of these linkages on the biophysical properties, biological properties, and some of the safety parameters.

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页码：927 / 936

页数：10

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