The telosome/shelterin complex and its functions

被引：162

作者：

Xin, Huawei ^{[1
]}

Liu, Dan ^{[1
,2
]}

Zhou Songyang ^{[1
]}

机构：

[1] Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Cell Based Assay Screening Serv Core, Houston, TX 77030 USA

来源：

GENOME BIOLOGY | 2008年 / 9卷 / 09期

关键词：

D O I：

10.1186/gb-2008-9-9-232

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting the chromosome ends and in intracellular signaling for regulating cell proliferation. A complex of six telomere-associated proteins has been identified - the telosome or shelterin complex - that is crucial for both the maintenance of telomere structure and its signaling functions.

引用

页数：7

共 93 条

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