Are mouse telomeres going to pot?

被引:13
作者
Baumann, Peter [1 ]
机构
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA
关键词
D O I
10.1016/j.cell.2006.06.027
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pot1 is a conserved single-stranded DNA binding protein with crucial functions in the protection of telomeres and maintenance of their length. In this issue of Cell, two papers (Hockemeyer et al., 2006; Wu et al., 2006) examine the roles of murine Pot1 homologs and describe intriguing new insights into how cells protect their chromosome ends from DNA-repair activities.
引用
收藏
页码:33 / 36
页数:4
相关论文
共 15 条
[1]   Pot1, the putative telomere end-binding protein in fission yeast and humans [J].
Baumann, P ;
Cech, TR .
SCIENCE, 2001, 292 (5519) :1171-1175
[2]   Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stability [J].
Bunch, JT ;
Bae, NS ;
Leonardi, J ;
Baumann, P .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (13) :5567-5578
[3]   Beginning to understand the end of the chromosome [J].
Cech, TR .
CELL, 2004, 116 (02) :273-279
[4]   DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion [J].
Celli, GB ;
de Lange, T .
NATURE CELL BIOLOGY, 2005, 7 (07) :712-U110
[5]   Shelterin: the protein complex that shapes and safeguards human telomeres [J].
de Lange, T .
GENES & DEVELOPMENT, 2005, 19 (18) :2100-2110
[6]   T-loops and the origin of telomeres [J].
de Lange, T .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (04) :323-329
[7]   A means to a DNA end: The many roles of Ku [J].
Downs, JA ;
Jackson, SP .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (05) :367-378
[8]   POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end [J].
Hockemeyer, D ;
Sfeir, AJ ;
Shay, JW ;
Wright, WE ;
de Lange, T .
EMBO JOURNAL, 2005, 24 (14) :2667-2678
[9]   The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response [J].
Karlseder, J ;
Hoke, K ;
Mirzoeva, OK ;
Bakkenist, C ;
Kastan, MB ;
Petrini, JHJ ;
de Lange, T .
PLOS BIOLOGY, 2004, 2 (08) :1150-1156
[10]   Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection [J].
Lei, M ;
Podell, ER ;
Cech, TR .
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (12) :1223-1229