A means to a DNA end: The many roles of Ku

被引：300

作者：

Downs, JA

Jackson, SP

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England

[2] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QR, England

[3] Univ Cambridge, Dept Zool, Cambridge CB2 1QR, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2004年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrm1367

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ku is of central importance to DNA repair in eukaryotes. In addition, Ku has a key role in a number of other fundamental cellular processes such as telomere maintenance, transcription and apoptosis. The mechanism by which Ku mediates these processes is not entirely understood, but the current knowledge indicates that the function of Ku in these processes might be mechanistically related to its role in DNA repair. Interestingly, recent findings showed that Ku also exists in Archaea and Bacteria, shedding light on aspects of its conservation and evolution.

引用

页码：367 / 378

页数：12

共 125 条

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