The mechanism and regulation of chromosomal V(D)J recombination

被引：717

作者：

Bassing, CH ^{[1
]}

Swat, W ^{[1
]}

Alt, FW ^{[1
]}

机构：

[1] Childrens Hosp, Ctr Blood Res, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CELL | 2002年 / 109卷

关键词：

D O I：

10.1016/S0092-8674(02)00675-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease.

引用

页码：S45 / S55

页数：11

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