Synthesis of the enantiopure C15-C26 segment of phorboxazole A and B

被引：50

作者：

Wolbers, P ^{[1
]}

Misske, AM ^{[1
]}

Hoffmann, HMR ^{[1
]}

机构：

[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 24期

关键词：

marine macrolides; oxazole synthesis; stereocontrol; HWE olefination;

D O I：

10.1016/S0040-4039(99)00803-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two approaches towards an enantiopure C15-C26 segment of the phorboxazoles starting from the corresponding C20-C26 aldehyde are presented. A variety of functionalized oxazoles have been synthesized via the rhodium(II) acetate catalyzed cycloaddition of dimethyl diazomalonate to substituted nitriles. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4527 / 4530

页数：4