Drug-induced arrhythmia: pharmacogenomic prescribing?

被引：56

作者：

Behr, Elijah R. ^{[1
]}

Roden, Dan ^{[2
,3
,4
]}

机构：

[1] St Georges Univ London, Cardiovasc Sci Res Ctr, London SW17 0RE, England

[2] Vanderbilt Univ, Dept Med, Sch Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Dept Pharmacol, Sch Med, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Off Personalized Med, Sch Med, Nashville, TN 37232 USA

来源：

EUROPEAN HEART JOURNAL | 2013年 / 34卷 / 02期

关键词：

Torsades de pointes; Serious adverse events; Anti-arrhythmic drugs; Pharmacogenomics; Drug-induced arrhythmia; Acquired long QT syndrome; LONG-QT-SYNDROME; TORSADES-DE-POINTES; SUDDEN CARDIAC DEATH; REPOLARIZATION RESERVE; INTERVAL DURATION; REGULATORY IMPLICATIONS; ANTIARRHYTHMIC DRUGS; GENETIC-VARIATIONS; POLICY CONFERENCE; NONCARDIAC DRUGS;

D O I：

10.1093/eurheartj/ehs351

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Drug-induced Torsades de Pointes is a rare, unpredictable, and life-threatening serious adverse event. It can be caused by both cardiac and non-cardiac drugs and has become a major issue in novel drug development and for the regulatory authorities. This review describes the problem, predisposing factors, and the underlying genetic predisposition as it is understood currently. The future potential for pharmacogenomic-guided and personalized prescription to prevent drug-induced Torsades de Pointes is discussed. Database searches utilized reports from up to January 2012, case reports and articles from up to January 2012, and the British National Formulary edition at .

引用

页码：89 / +

页数：9

共 70 条

[1]

CLINICAL RELEVANCE OF CARDIAC-ARRHYTHMIAS GENERATED BY AFTERDEPOLARIZATIONS - ROLE OF M-CELLS IN THE GENERATION OF U WAVES, TRIGGERED ACTIVITY AND TORSADE-DE-POINTES [J].

ANTZELEVITCH, C ;

SICOURI, S .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 23 (01) :259-277

[2]

Cellular basis for the repolarization waves of the ECG [J].

Antzelevitch, Charles .

INTERACTIVE AND INTEGRATIVE CARDIOLOGY, 2006, 1080 :268-281

[3]

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization [J].

Arking, Dan E. ;

Pfeufer, Arne ;

Post, Wendy ;

Kao, W. H. Linda ;

Newton-Cheh, Christopher ;

Ikeda, Morna ;

West, Kristen ;

Kashuk, Carl ;

Akyol, Mahmut ;

Perz, Siegfried ;

Jalilzadeh, Shapour ;

Illig, Thomas ;

Gieger, Christian ;

Guo, Chao-Yu ;

Larson, Martin G. ;

Wichmann, H. Erich ;

Marban, Eduardo ;

O'Donnell, Christopher J. ;

Hirschhorn, Joel N. ;

Kaeaeb, Stefan ;

Spooner, Peter M. ;

Meitinger, Thomas ;

Chakravarti, Aravinda .

NATURE GENETICS, 2006, 38 (06) :644-651

[4]

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes [J].

Behr, Elijah R. ;

January, Craig ;

Schulze-Bahr, Eric ;

Grace, Andrew A. ;

Kaeaeb, Stefan ;

Fiszman, Monica ;

Gathers, Shaniece ;

Buckman, ShaAvhree ;

Youssef, Ashraf ;

Pirmohamed, Munir ;

Roden, Dan .

EUROPEAN HEART JOURNAL, 2013, 34 (26) :1958-1963

[5]

Behr ER, 2012, PRINCIPLES PRACTICE, P261

[6]

BROADHURST P, 1993, BRIT HEART J, V70, P469

[7]

ARRHYTHMOGENESIS OF ANTIARRHYTHMIC DRUGS [J].

BRUGADA, P ;

WELLENS, HJJ .

AMERICAN JOURNAL OF CARDIOLOGY, 1988, 61 (13) :1108-1111

[8]

CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart [J].

Chang, Kuan-Cheng ;

Barth, Andreas S. ;

Sasano, Tetsuo ;

Kizana, Eddy ;

Kashiwakura, Yuji ;

Zhang, Yiqiang ;

Foster, D. Brian ;

Marban, Eduardo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (11) :4477-4482

[9]

Carbamazepine-Induced Toxic Effects and HLA-B*1502 Screening in Taiwan [J].

Chen, Pei ;

Lin, Juei-Jueng ;

Lu, Chin-Song ;

Ong, Cheung-Ter ;

Hsieh, Peiyuan F. ;

Yang, Chih-Chao ;

Tai, Chih-Ta ;

Wu, Shey-Lin ;

Lu, Cheng-Hsien ;

Hsu, Yung-Chu ;

Yu, Hsiang-Yu ;

Ro, Long-Sun ;

Lu, Chung-Ta ;

Chu, Chun-Che ;

Tsai, Jing-Jane ;

Su, Yu-Hsiang ;

Lan, Sheng-Hsing ;

Sung, Sheng-Feng ;

Lin, Shu-Yi ;

Chuang, Hui-Ping ;

Huang, Li-Chen ;

Chen, Ying-Ju ;

Tsai, Pei-Joung ;

Liao, Hung-Ting ;

Lin, Yu-Hsuan ;

Chen, Chien-Hsiun ;

Chung, Wen-Hung ;

Hung, Shuen-Iu ;

Wu, Jer-Yuarn ;

Chang, Chi-Feng ;

Chen, Luke ;

Chen, Yuan-Tsong ;

Shen, Chen-Yang .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (12) :1126-1133

[10]

NOS1AP Is a Genetic Modifier of the Long-QT Syndrome [J].

Crotti, Lia ;

Monti, Maria Cristina ;

Insolia, Roberto ;

Peljto, Anna ;

Goosen, Althea ;

Brink, Paul A. ;

Greenberg, David A. ;

Schwartz, Peter J. ;

George, Alfred L., Jr. .

CIRCULATION, 2009, 120 (17) :1657-1663

← 1 2 3 4 5 6 7 →