Extracellular proteolysis and the migrating vascular smooth muscle cell

被引:41
作者
vanLeeuwen, RTJ
机构
[1] Gaubius Laboratory, TNO-PG, Leiden
[2] Gaubius Laboratory, TNO-PG, 2301 CE Leiden
关键词
D O I
10.1016/S0268-9499(96)80081-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Smooth muscle cells (SMC) form the major cell type in the arterial blood vessels. In the undamaged vessel wall they remain in a contractile state characterized by the absence of cell division, a low metabolic activity and a high actin-myosin content. As a reaction to injury of the vessel wall they can, however, change their phenotype and start to proliferate and migrate through the vessel wall from the media towards the intima. Extracellular proteolysis is increased during the migration of SMCs and local lysis of the surrounding extracellular matrix is observed. The SMC produces several proteases during migration, especially plasminogen activators and metalloproteinases. Many growth factors and cytokines can modulate the production and activation of extracellular proteinases and their inhibitors in the activated vascular SMC. The production and regulation of the extracellular proteolytic enzymes by SMCs in relation to cell migration are discussed in this review.
引用
收藏
页码:59 / 74
页数:16
相关论文
共 196 条
  • [41] KINETICS OF CELLULAR PROLIFERATION AFTER ARTERIAL INJURY .4. HEPARIN INHIBITS RAT SMOOTH-MUSCLE MITOGENESIS AND MIGRATION
    CLOWES, AW
    CLOWES, MM
    [J]. CIRCULATION RESEARCH, 1986, 58 (06) : 839 - 845
  • [42] SMOOTH-MUSCLE CELLS EXPRESS UROKINASE DURING MITOGENESIS AND TISSUE-TYPE PLASMINOGEN-ACTIVATOR DURING MIGRATION IN INJURED RAT CAROTID-ARTERY
    CLOWES, AW
    CLOWES, MM
    AU, YPT
    REIDY, MA
    BELIN, D
    [J]. CIRCULATION RESEARCH, 1990, 67 (01) : 61 - 67
  • [43] SIGNIFICANCE OF QUIESCENT SMOOTH-MUSCLE MIGRATION IN THE INJURED RAT CAROTID-ARTERY
    CLOWES, AW
    SCHWARTZ, SM
    [J]. CIRCULATION RESEARCH, 1985, 56 (01) : 139 - 145
  • [44] CLOWES AW, 1991, THROMB HAEMOSTASIS, V66, P62
  • [45] CLYMAN RI, 1994, J CELL SCI, V107, P1007
  • [46] INTEGRIN RECEPTORS ON AORTIC SMOOTH-MUSCLE CELLS MEDIATE ADHESION TO FIBRONECTIN, LAMININ, AND COLLAGEN
    CLYMAN, RI
    MCDONALD, KA
    KRAMER, RH
    [J]. CIRCULATION RESEARCH, 1990, 67 (01) : 175 - 186
  • [47] CRUTCHLEY DJ, 1986, J BIOL CHEM, V261, P154
  • [48] CUNNINGHAM DD, 1993, THROMB HAEMOSTASIS, V70, P168
  • [49] PLASMINOGEN ACTIVATORS, TISSUE DEGRADATION, AND CANCER
    DANO, K
    ANDREASEN, PA
    GRONDAHLHANSEN, J
    KRISTENSEN, P
    NIELSEN, LS
    SKRIVER, L
    [J]. ADVANCES IN CANCER RESEARCH, 1985, 44 : 139 - 266
  • [50] DARLAK K, 1990, J BIOL CHEM, V265, P5199