Heterogeneity of ICAM-1 expression, and cytokine regulation of ICAM-1 expression, in skin and oral keratinocytes

被引：27

作者：

Li, J

Mahiouz, DL

Farthing, PM

Haskard, DO

Thornhill, MH

机构：

[1] UNIV MANCHESTER, SCH DENT SCI, CLIN ACAD GRP ORAL MED & DENT DIAGNOST SCI, MANCHESTER M15 6FH, LANCS, ENGLAND

[2] ROYAL POSTGRAD MED SCH, DEPT RHEUMATOL, LONDON, ENGLAND

[3] LONDON HOSP, COLL MED, DEPT ORAL PATHOL, LONDON E1 1BB, ENGLAND

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 1996年 / 25卷 / 03期

基金：

英国惠康基金;

关键词：

ICAM-1; keratinocytes; messenger RNA; mucosa;

D O I：

10.1111/j.1600-0714.1996.tb00204.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Differences in expression of intercellular adhesion molecule-1 (ICAM-1) and ICAM-1 mRNA levels were studied in cultured skin and oral keratinocytes before and after stimulation with different pro-inflammatory cytokines. Basal expression of ICAM-1 was undetectable on skin keratinocytes but oral keratinocytes expressed ICAM-1 at high levels. Interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) increased ICAM-1 expression on both cell types, although TNF-alpha had a greater effect on oral than skin keratinocytes (P<0.05) and IFN-gamma was more effective than TNF-alpha on both cell types (P<0.01). In combination, TNF-alpha and IFN-gamma synergistically increased ICAM-1 expression on skin keratinocytes only, although ICAM-1 mRNA was synergistically increased in both cell types. IL-1 alpha and IL-1 beta induced a small increase in ICAM-1 expression on oral keratinocytes but had no effect on skin keratinocytes. (C) Munksgaard, 1996.

引用

页码：112 / 118

页数：7