Haplosamates A and B: New steroidal sulfamate esters from two haplosclerid sponges

被引：42

作者：

Qureshi, A ^{[1
]}

Faulkner, DJ ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

来源：

TETRAHEDRON | 1999年 / 55卷 / 28期

关键词：

sponges; marine metabolites; steroids and sterols; NMR;

D O I：

10.1016/S0040-4020(99)00465-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two sponges from the Philippines, one a Xestospongia sp. Haplosclerida, Petrosiidae and the other an unidentified haplosclerid sponge, both contained the unusual steroidal sulfamate esters, haplosamates A (1) and B (2), the structures of which were determined by interpretation of spectral data. Haplosamates A (1) and B (2) inhibit HIV-I integrase with IC50's of 50 mu g/mL and 15 mu g/mL, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：8323 / 8330

页数：8

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