p53: The Janus of autophagy?

被引：176

作者：

Levine, Beth ^{[1
,2
]}

Abrams, John ^{[3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 06期

关键词：

D O I：

10.1038/ncb0608-637

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

引用

页码：637 / 639

页数：4

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