Diastereoselective cationic tandem cyclizations to N-heterocyclic scaffolds:: Total synthesis of (-)-dysibetaine PP

被引：34

作者：

IJzendoorn, DR ^{[1
]}

Botman, PNM ^{[1
]}

Blaauw, RH ^{[1
]}

机构：

[1] Chiralix BV, NL-6503 CB Nijmegen, Netherlands

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 02期

关键词：

D O I：

10.1021/ol052598r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a short and diastereoselective synthesis of the natural product (-)-dysibetaine PP. The key step in the synthetic sequence is a novel highly diastereoselective tandem-cyclization reaction of an enantiomerically pure dipeptide. This cyclization methodology is applied in the synthesis of a broader range of N-heterocyclic scaffolds.

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页码：239 / 242

页数：4

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