Diastereoselective synthesis of (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives

被引：39

作者：

Botman, PNM

Dommerholt, FJ

de Gelder, R

Broxterman, QB

Schoemaker, HE

Rutjes, FPJT

Blaauw, RH

机构：

[1] Chiralix BV, NL-6503 CB Nijmegen, Netherlands

[2] Radbound Univ, IMM, NL-6525 ED Nijmegen, Netherlands

[3] DSM Res BV, Life Sci Adv Synt Catalysis & Dev, NL-6160 MD Geleen, Netherlands

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 26期

关键词：

D O I：

10.1021/ol047774v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a diastereoselective synthesis of the natural product (2S,5R)-5-hydroxypipecolic acid and 6-substituted derivatives thereof. The key step in the synthetic sequence is a novel highly diastereoselective epoxidation reaction of an enantiomerically pure cyclic enamide intermediate.

引用

页码：4941 / 4944

页数：4

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