A chiral relay auxiliary for the synthesis of homochiral α-amino acids

被引：67

作者：

Bull, SD

Davies, SG

Epstein, SW

Leech, MA

Ouzman, JVA

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Univ Oxford, Chem Crystallog Lab, Oxford OX1 3PD, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 15期

关键词：

D O I：

10.1039/a803124j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new chiral auxiliary (3S)-N,N'-bis(p-methoxybenzyl)-3-isopropylpiperazine-2,5-dione 7 has been developed for the asymmetric synthesis of a-amino acids. The auxiliary 7 employs a novel chiral relay network based on non-stereogenic N-benzyl protecting groups which enhance the diastereoselectivity observed during alkylation of its C-6 enolate 25.

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页码：2321 / 2330

页数：10

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