Practical synthesis of Schollkopf's bis-lactim ether chiral auxiliary: (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine

被引：45

作者：

Bull, SD

Davies, SG

Moss, WO

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Zeneca Pharmaceut, Macclesfield SK10 2NA, Cheshire, England

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(97)00623-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Practical methodology for the bis-O-methylation of (3S)-isopropyl-piperazine-2,5-dione 4 on a 45 g scale to generate Schollkopf's bis-lactim ether chiral auxiliary (3S)-3,6-dihydro-2,5-dimethoxy-3-isopropyl-pyrazine 1 has been developed. Monomethylated intermediates 5 and 6 are reported for the first time. The gelling effects of 4 in a range of common solvents are also described. (C) 1998 Elsevier Science Ltd. kll rights reserved.

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页码：321 / 327

页数：7

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