SYNTHESIS OF 6,5-FUSED BICYCLIC LACTAMS AS POTENTIAL DIPEPTIDE BETA-TURN MIMETICS

被引：50

作者：

MUELLER, R ^{[1
]}

REVESZ, L ^{[1
]}

机构：

[1] SANDOZ RES INST BERNE,CH-3007 BERN,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(00)73120-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first short synthesis of the dipeptide mimetic (3S,6S,9S)-6-amino-5-oxoindolizidine-3-carboxylic acid 1 and its Z-protected derivative 9 is described, employing the Schoellkopf bislactim-ether methodology, followed by a highly specific intramolecular reductive amination and spontaneous lactamization. These 6,5-fused bicyclic lactams may be viewed as conformationally restricted alanyl-proline beta-turn mimetics.

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页码：4091 / 4092

页数：2

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