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Gene therapy for cardiovascular disorders - Is there a future?

被引：9
作者：
Metcalfe, BL
Sellers, KW
Jeng, MJR
Huentelman, MJ
Katovich, MJ
Raizada, MK
机构：
[1] Univ Florida, Coll Med, Dept Physiol & Funct Genom, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Pharm, Evelyn F & William Mcknight Brain Inst, Dept Pharmacodynam, Gainesville, FL 32610 USA
来源：
NEW VISTAS IN THERAPEUTICS, FROM DRUG DESIGN TO GENE THERAPY: DRUG-RESISTANT TUBERCULOSIS, FROM MOLECULES TO MACRO-ECONOMICS | 2001年 / 953卷
关键词：
gene therapy; cardiovascular disorders; viral vectors; restenosis; thrombosis; hypertension; ischemia; heart failure;
D O I：
10.1111/j.1749-6632.2001.tb11358.x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Incidence of cardiovascular disease has reached epidemic proportions in spite of recent advances in improving the efficacy of pharmacotherapeutics. This has led many to conclude that drug therapy has reached a plateau in its effectiveness. As a result, our efforts have been diverted to explore the use of gene transfer approaches for long-term control of these pathophysiological conditions. The purpose of this review is to present various approaches that are being undertaken to provide "proof of principle" for gene therapy for cardiovascular diseases. Finally, we will discuss the future of gene therapy and other new technologies that may further advance this field of therapeutics.
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页码：31 / 42
页数：12
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