Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances

被引：125

作者：

Patel, RN ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res, Inst New Brunswick, Proc Res & Dev, New Brunswick, NJ 08903 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(01)00266-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity. Chiral intermediates and fine chemicals are in high demand, both from the pharmaceutical and agrochemical industries, for the preparation of bulk drug substances and agricultural products. Biocatalytic processes have been described for the synthesis of chiral intermediates for beta3- and beta2-receptor agonists, anti hypertensive drugs, antiviral agents, melatonin receptor agonists, anticholesterol and anticancer drugs, and drugs to treat Alzheimer's disease.

引用

页码：587 / 604

页数：18

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