Defining stem cell types: understanding the therapeutic potential of ESCs, ASCs, and iPS cells

被引：61

作者：

Alvarez, Clara V. ^{[1
,2
]}

Garcia-Lavandeira, Montserrat ^{[1
,2
]}

Garcia-Rendueles, Maria E. R. ^{[1
,2
]}

Diaz-Rodriguez, Esther ^{[1
,2
]}

Garcia-Rendueles, Angela R. ^{[1
,2
]}

Perez-Romero, Sihara ^{[1
,2
]}

Vila Vila, Tania ^{[1
,2
]}

Rodrigues, Joana S. ^{[1
,2
]}

Lear, Pamela V. ^{[1
,2
,3
,4
]}

Bravo, Susana B. ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela USC, Ctr Invest Med, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela USC, Inst Invest Sanitarias CIMUS IDIS, Dept Physiol, Santiago De Compostela 15782, Spain

[3] Univ Santiago de Compostela USC, Dept Cardiol, Santiago De Compostela 15782, Spain

[4] Hosp Clin CHUS, Santiago De Compostela, Spain

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2012年 / 49卷 / 02期

关键词：

HEMATOPOIETIC STEM; SELF-RENEWAL; BETA-CATENIN; IN-VIVO; PROGENITOR CELLS; DOPAMINERGIC-NEURONS; ANALYSIS REVEALS; SMALL-INTESTINE; MOUSE EPIBLAST; GROUND-STATE;

D O I：

10.1530/JME-12-0072

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Embryonic, adult, artificially reprogrammed, and cancer. . . -there are various types of cells associated with stemness. Do they have something fundamental in common? Are we applying a common name to very different entities? In this review, we will revisit the characteristics that define 'pluripotency', the main property of stem cells (SCs). For each main type of physiological (embryonic and adult) or synthetic (induced pluripotent) SCs, markers and functional behavior in vitro and in vivo will be described. We will review the pioneering work that has led to obtaining human SC lines, together with the problems that have arisen, both in a biological context (DNA alterations, heterogeneity, tumors, and immunogenicity) and with regard to ethical concerns. Such problems have led to proposals for new operative procedures for growing human SCs of sufficiently high quality for use as models of disease and in human therapy. Finally, we will review the data from the first clinical trials to use various types of SCs. Journal of Molecular Endocrinology (2012) 49, R89-R111

引用

页码：R89 / R111

页数：23

共 156 条

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