Unraveling epigenetic regulation in embryonic stem cells

被引：135

作者：

Bibikova, Marina ^{[1
]}

Laurent, Louise C. ^{[2
,3
]}

Ren, Bing ^{[4
,5
]}

Loring, Jeanne F. ^{[2
]}

Fan, Jian-Bing ^{[1
]}

机构：

[1] Illumina Inc, San Diego, CA 92121 USA

[2] Scripps Res Inst, Ctr Regenerat Med, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Reprod Med, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[5] Univ Calif San Diego, Dept Cell & Mol Med, La Jolla, CA 92093 USA

来源：

CELL STEM CELL | 2008年 / 2卷 / 02期

关键词：

D O I：

10.1016/j.stem.2008.01.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to differentiate into functionally distinct cell types. ES cells proliferate and differentiate without detectable genetic changes, indicating that these processes are controlled by epigenetic factors. Here we describe what is known about the epigenetics of ES cells and speculate that a dynamic balance among at least three epigenetic elements (chromatin structure, DNA methylation, and microRNAs), in conjunction with transcription factors, contributes to the maintenance of pluripotence. Understanding the interactions among these factors will be critical to the development of improved strategies to reprogram differentiated cells or direct differentiation of pluripotent cells.

引用

页码：123 / 134

页数：12

共 99 条

[1] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [J].

Adewumi, Oluseun ;

Aflatoonian, Behrouz ;

Ahrlund-Richter, Lars ;

Amit, Michal ;

Andrews, Peter W. ;

Beighton, Gemma ;

Bello, Paul A. ;

Benvenisty, Nissim ;

Berry, Lorraine S. ;

Bevan, Simon ;

Blum, Barak ;

Brooking, Justin ;

Chen, Kevin G. ;

Choo, Andre B. H. ;

Churchill, Gary A. ;

Corbel, Marie ;

Damjanov, Ivan ;

Draper, Jon S. ;

Dvorak, Petr ;

Emanuelsson, Katarina ;

Fleck, Roland A. ;

Ford, Angela ;

Gertow, Karin ;

Gertsenstein, Marina ;

Gokhale, Paul J. ;

Hamilton, Rebecca S. ;

Hampl, Ales ;

Healy, Lyn E. ;

Hovatta, Outi ;

Hyllner, Johan ;

Imreh, Marta P. ;

Itskovitz-Eldor, Joseph ;

Jackson, Jamie ;

Johnson, Jacqueline L. ;

Jones, Mark ;

Kee, Kehkooi ;

King, Benjamin L. ;

Knowles, Barbara B. ;

Lako, Majlinda ;

Lebrin, Franck ;

Mallon, Barbara S. ;

Manning, Daisy ;

Mayshar, Yoav ;

Mckay, Ronald D. G. ;

Michalska, Anna E. ;

Mikkola, Milla ;

Mileikovsky, Masha ;

Minger, Stephen L. ;

Moore, Harry D. ;

Mummery, Christine L. .

NATURE BIOTECHNOLOGY, 2007, 25 (07) :803-816

[2] UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [J].

Agger, Karl ;

Cloos, Paul A. C. ;

Christensen, Jesper ;

Pasini, Diego ;

Rose, Simon ;

Rappsilber, Juri ;

Issaeva, Irina ;

Canaani, Eli ;

Salcini, Anna Elisabetta ;

Helin, Kristian .

NATURE, 2007, 449 (7163) :731-U10

[3] Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome [J].

Allegrucci, Cinzia ;

Wu, Yue-Zhong ;

Thurston, Alexandra ;

Denning, Chris N. ;

Priddle, Helen ;

Mummery, Christine L. ;

Ward-van Oostwaard, Dorien ;

Andrews, Peter W. ;

Stojkovic, Miodrag ;

Smith, Nigel ;

Parkin, Tony ;

Edmondson Jones, Mark ;

Warren, Graham ;

Yu, Li ;

Brena, Romulo Martin ;

Plass, Christoph ;

Young, Lorraine E. .

HUMAN MOLECULAR GENETICS, 2007, 16 (10) :1253-1268

[4] Chromatin signatures of pluripotent cell lines [J].

Azuara, V ;

Perry, P ;

Sauer, S ;

Spivakov, M ;

Jorgensen, HF ;

John, RM ;

Gouti, M ;

Casanova, M ;

Warnes, G ;

Merkenschlager, M ;

Fisher, AG .

NATURE CELL BIOLOGY, 2006, 8 (05) :532-U189

[5] High-resolution profiling of histone methylations in the human genome [J].

Barski, Artern ;

Cuddapah, Suresh ;

Cui, Kairong ;

Roh, Tae-Young ;

Schones, Dustin E. ;

Wang, Zhibin ;

Wei, Gang ;

Chepelev, Iouri ;

Zhao, Keji .

CELL, 2007, 129 (04) :823-837

[6] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[7] Whole-genome re-sequencing [J].

Bentley, David R. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (06) :545-552

[8] The complex language of chromatin regulation during transcription [J].

Berger, Shelley L. .

NATURE, 2007, 447 (7143) :407-412

[9] A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].

Bernstein, BE ;

Mikkelsen, TS ;

Xie, XH ;

Kamal, M ;

Huebert, DJ ;

Cuff, J ;

Fry, B ;

Meissner, A ;

Wernig, M ;

Plath, K ;

Jaenisch, R ;

Wagschal, A ;

Feil, R ;

Schreiber, SL ;

Lander, ES .

CELL, 2006, 125 (02) :315-326

[10] The mammalian epigenome [J].

Bernstein, Bradley E. ;

Meissner, Alexander ;

Lander, Eric S. .

CELL, 2007, 128 (04) :669-681

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