The 1-1-1 fallacy

被引：32

作者：

Crotty, Shane ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol LIAI, Div Vaccine Discovery, La Jolla, CA 92037 USA

来源：

IMMUNOLOGICAL REVIEWS | 2012年 / 247卷

关键词：

germinal centers; plasma cells; CD4+T-cell differentiation; IL-21; Maf; vaccines; FOLLICULAR HELPER-CELL; CENTER B-CELL; FACTOR C-MAF; FACTOR BATF CONTROLS; CD4(+) T-CELLS; GERMINAL-CENTER; TRANSCRIPTION FACTOR; IN-VIVO; INFECTIOUS-DISEASES; MYELOID-LEUKEMIA;

D O I：

10.1111/j.1600-065X.2012.01117.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T-cell help to B cells is a fundamental aspect of adaptive immunity and the generation of B-cell memory (memory B cells and plasma cells). Follicular helper CD4+ T (Tfh) cells are the specialized providers of B-cell help, and Tfh cells depend on Bcl6 for their differentiation. This review discusses Tfh cell functions, transcription factors, and induction signals, with particular focus on the richness of the underlying biology and assessing the simplicity or complexity of each of these processes.

引用

页码：133 / 142

页数：10

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