4-aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors

被引：21

作者：

Hashimoto, H ^{[1
]}

Maeda, K ^{[1
]}

Ozawa, K ^{[1
]}

Haruta, J ^{[1
]}

Wakitani, K ^{[1
]}

机构：

[1] JT Inc, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(01)00670-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：65 / 68

页数：4

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