DIARYL INDENES AND BENZOFURANS - NOVEL CLASSES OF POTENT AND SELECTIVE CYCLOOXYGENASE-2 INHIBITORS

被引：65

作者：

HUANG, HC ^{[1
]}

CHAMBERLAIN, TS ^{[1
]}

SEIBERT, K ^{[1
]}

KOBOLDT, CM ^{[1
]}

ISAKSON, PC ^{[1
]}

REITZ, DB ^{[1
]}

机构：

[1] INFLAMMATORY DIS RES,ST LOUIS,MO 63198

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 20期

关键词：

D O I：

10.1016/0960-894X(95)00414-O

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel series of diaryl indenes and benzofurans have been shown to be potent and selective COX-2 inhibitors. A structure-activity relationship study suggests that the conversion of sulfones to sulfonamides affords potent, but slightly less selective COX-2 inhibitors, and that for benzofurans the 3-halo-4-metholryphenyl sulfonamide analogs are more selective than the corresponding 4-fluorophenyl analog.

引用

页码：2377 / 2380

页数：4

共 19 条

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