Regeneration in heart disease-Is ECM the key?

被引：51

作者：

Bayomy, Ahmad F. ^{[1
,2
]}

Bauer, Michael ^{[1
]}

Qiu, Yiling ^{[1
]}

Liao, Ronglih ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Cardivasc Div,Cardiac Muscle Res Lab, Boston, MA 02115 USA

[2] Univ Washington, Sch Med, Seattle, WA 98195 USA

来源：

LIFE SCIENCES | 2012年 / 91卷 / 17-18期

基金：

美国国家卫生研究院;

关键词：

Regeneration; Cardiac progenitor cell; Extracellular matrix; Heart disease; EMBRYONIC STEM-CELLS; EXTRACELLULAR-MATRIX PROTEINS; RAT VENTRICULAR MYOCYTES; PROGENITOR CELLS; BONE-MARROW; IN-VITRO; HYPERTROPHIC RESPONSE; MYOCARDIAL-INFARCTION; PRESSURE-OVERLOAD; BETA(1) INTEGRINS;

D O I：

10.1016/j.lfs.2012.08.034

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The heart possesses a regeneration potential derived from endogenous and exogenous stem and progenitor cell populations, though baseline regeneration appears to be sub-therapeutic. This limitation was initially attributed to a lack of cells with cardiomyogenic potential following an insult to the myocardium. Rather, recent studies demonstrate increased numbers of cardiomyocyte progenitor cells in diseased hearts. Given that the limiting factor does not appear to be cell quantity but rather repletion of functional cardiomyocytes, it is crucial to understand potential mechanisms inhibiting progenitor cell differentiation. One of the extensively studied areas in heart disease is extracellular matrix (ECM) remodeling, with both the composition and mechanical properties of the ECM undergoing changes in diseased hearts. This review explores the influence of ECM properties on cardiomyogenesis and adult cardiac progenitor cells. (C) 2012 Elsevier Inc. All rights reserved.

引用

收藏

页码：823 / 827

页数：5

相关论文

共 72 条

[1]

The effect of matrix composition of 3D constructs on embryonic stem cell differentiation [J].

Battista, S ;

Guarnieri, D ;

Borselli, C ;

Zeppetelli, S ;

Borzacchiello, A ;

Mayol, L ;

Gerbasio, D ;

Keene, DR ;

Ambrosio, L ;

Netti, PA .

BIOMATERIALS, 2005, 26 (31) :6194-6207

[2]

Matrix production and remodeling capacity of cardiomyocyte progenitor cells during in vitro differentiation [J].

Bax, Noortje A. M. ;

van Marion, Mieke H. ;

Shah, Bhakti ;

Goumans, Marie-Jose ;

Bouten, Carlijn V. C. ;

van der Schaft, Daisy W. J. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2012, 53 (04) :497-508

[3]

Human cardiac stem cells [J].

Bearzi, Claudia ;

Rota, Marcello ;

Hosoda, Toru ;

Tillmanns, Jochen ;

Nascirnbene, Angelo ;

De Angelis, Antonella ;

Yasuzawa-Amano, Saori ;

Trofimova, Irina ;

Siggins, Robert W. ;

LeCapitaine, Nicole ;

Cascapera, Stefano ;

Beltrami, Antonio P. ;

D'Alessandro, David A. ;

Zias, Elias ;

Quaini, Federico ;

Urbanek, Konrad ;

Michler, Robert E. ;

Bolli, Roberto ;

Kajstura, Jan ;

Leri, Annarosa ;

Anversa, Piero .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) :14068-14073

[4]

Evidence for Cardiomyocyte Renewal in Humans [J].

Bergmann, Olaf ;

Bhardwaj, Ratan D. ;

Bernard, Samuel ;

Zdunek, Sofia ;

Barnabe-Heider, Fanie ;

Walsh, Stuart ;

Zupicich, Joel ;

Alkass, Kanar ;

Buchholz, Bruce A. ;

Druid, Henrik ;

Jovinge, Stefan ;

Frisen, Jonas .

SCIENCE, 2009, 324 (5923) :98-102

[5]

Dynamic interactions between the cellular components of the heart and the extracellular matrix [J].

Borg, Thomas K. ;

Baudino, Troy A. .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2011, 462 (01) :69-74

[6]

Laying the Groundwork for Growth: Cell-Cell and Cell-ECM Interactions in Cardiovascular Development [J].

Bowers, Stephanie L. K. ;

Baudino, Troy A. .

BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 2010, 90 (01) :1-7

[7]

Sarcomere alignment is regulated by myocyte shape [J].

Bray, Mark-Anthony ;

Sheehy, Sean P. ;

Parker, Kevin Kit .

CELL MOTILITY AND THE CYTOSKELETON, 2008, 65 (08) :641-651

[8]

Nuclear morphology and deformation in engineered cardiac myocytes and tissues [J].

Bray, Mark-Anthony P. ;

Adams, William J. ;

Geisse, Nicholas A. ;

Feinberg, Adam W. ;

Sheehy, Sean P. ;

Parker, Kevin K. .

BIOMATERIALS, 2010, 31 (19) :5143-5150

[9]

Potential risks of bone marrow cell transplantation into infarcted hearts [J].

Breitbach, Martin ;

Bostani, Toktam ;

Roell, Wilhelm ;

Xia, Ying ;

Dewald, Oliver ;

Nygren, Jens M. ;

Fries, Jochen W. U. ;

Tiemann, Klaus ;

Bohlen, Heribert ;

Hescheler, Juergen ;

Welz, Armin ;

Bloch, Wilhelm ;

Jacobsen, Sten Eirik W. ;

Fleischmann, Bernd K. .

BLOOD, 2007, 110 (04) :1362-1369

[10]

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? [J].

Buxboim, Amnon ;

Ivanovska, Irena L. ;

Discher, Dennis E. .

JOURNAL OF CELL SCIENCE, 2010, 123 (03) :297-308

← 1 2 3 4 5 6 7 8 →