A novel route to functionalized PFP esters via rapid intermolecular radical addition to PFP acrylate mediated by ethylpiperidinium hypophosphite (EPHP)

被引：13

作者：

Caddick, S

Hamza, D

Judd, DB

Reich, MT

Wadman, SN

Wilden, JD

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

[3] Univ Sussex, Ctr Mol Design & Drug Dev, Brighton BN1 9QJ, E Sussex, England

[4] GlaxoSmithKline, High Throughput Chem, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 11期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

EPHP; radical; addition; amides; PFP esters;

D O I：

10.1016/j.tetlet.2004.01.082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pentafluorophenyl (PFP) acrylate, a stable compact bifunctional scaffold undergoes rapid N-ethylpiperidinium hypophosphite (EPHP) mediated conjugate radical addition to yield a variety of active esters susceptible to further functionalization by aminolysis. (C) 2004 Published by Elsevier Ltd.

引用

收藏

页码：2363 / 2366

页数：4

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