High resolution imaging of native biological sample surfaces using scanning probe microscopy

被引：146

作者：

Engel, A ^{[1
]}

Schoenenberger, CA ^{[1
]}

Muller, DJ ^{[1
]}

机构：

[1] FORSCHUNGSZENTRUM JULICH, FORSCHUNGSZENTRUM, IBI STRUCT BIOL 2, D-52425 JULICH, GERMANY

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(97)80037-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possibility of acquiring high resolution topographs using scanning probe microscopes under physiological conditions allows the observation of biomolecules at work. Progress has recently been made in imaging protein-DNA complexes, individual oligomers and protein arrays. Scanning probe microscopes are now tools that complement X-ray crystallography and electron microscopy.

引用

页码：279 / 284

页数：6

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