Synthesis of the mannosyl erythritol lipid MEL A;: confirmation of the configuration of the meso-erythritol moiety

被引：41

作者：

Crich, D

de la Mora, MA

Cruz, R

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

[2] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

TETRAHEDRON | 2002年 / 58卷 / 01期

基金：

美国国家卫生研究院;

关键词：

mannosyl erythritol lipid; meso-erythritol; biosurfactant;

D O I：

10.1016/S0040-4020(01)01087-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of the two possible diastereomers of mannosylerythritol lipid A, a novel biosurfactant from Candida antartica T-34 with promising anti-proliferative properties in several cell lines, is described. By comparison with an authentic sample, the natural material is confirmed as a single diastereomer with the 4-O-(beta -D-mannopyranosyl) D-erythritol configuration. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：35 / 44

页数：10

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