Mossy fibre sprouting: Evidence against a facilitatory role in epileptogenesis

被引：54

作者：

Elmer, E ^{[1
]}

Kokaia, Z ^{[1
]}

Kokaia, M ^{[1
]}

Lindvall, O ^{[1
]}

McIntyre, DC ^{[1
]}

机构：

[1] CARLETON UNIV,DEPT PSYCHOL,OTTAWA,ON K1S 5B6,CANADA

来源：

NEUROREPORT | 1997年 / 8卷 / 05期

关键词：

dentate gyrus; epilepsy; granule cells; kindling; mossy fibres; plasticity;

D O I：

10.1097/00001756-199703240-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SPROUTING of messy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Messy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed messy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of messy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that messy fibre sprouting facilitates epileptogenesis.

引用

页码：1193 / 1196

页数：4