Cytokine profile of Armenian patients with familial Mediterranean fever

被引：53

作者：

Manukyan, G. P. ^{[2
,3
]}

Ghazaryan, K. A. ^{[2
,3
]}

Ktsoyall, Zh. A. ^{[2
,3
]}

Tatyan, M. V. ^{[2
,3
]}

Khachatryan, Z. A. ^{[2
,3
]}

Hakobyan, G. S. ^{[4
]}

Mkrtchyan, V. A. ^{[5
]}

Kelly, D. ^{[1
]}

Coutts, A. ^{[1
]}

Aminov, R. I. ^{[1
]}

机构：

[1] Rowett Res Inst, Aberdeen AB21 9SB, Scotland

[2] Natl Acad Sci, Inst Mol Biol, Grp Mol & Cellular Immunol, Yerevan, Armenia

[3] Natl Acad Sci, Inst Mol Biol, Mol Genet Lab, Yerevan, Armenia

[4] Med Ctr Armenia, Dept Gastroenterol & Familial Mediterranean Fever, Yerevan, Armenia

[5] Inst Cardiol, Immunol Lab, Yerevan, Armenia

来源：

CLINICAL BIOCHEMISTRY | 2008年 / 41卷 / 10-11期

关键词：

familial Mediterranean fever; sera; ELISA; CBA; cytokines;

D O I：

10.1016/j.clinbiochem.2008.03.017

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. Design and methods: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA). Results: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission. Conclusions: Inflammation in FNIF involves Treg and Th17 lineages. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：920 / 922

页数：3

共 10 条

[1] The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease [J].

Afzali, B. ;

Lombardi, G. ;

Lechler, R. I. ;

Lord, G. M. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 148 (01) :32-46

[2] Continuity of cytokine activation in patients with familial Mediterranean fever [J].

Bagci, S ;

Toy, B ;

Tuzun, A ;

Ates, Y ;

Aslan, M ;

Inal, A ;

Gulsen, M ;

Karaeren, N ;

Dagalp, K .

CLINICAL RHEUMATOLOGY, 2004, 23 (04) :333-337

[3] The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1β production [J].

Chae, Jae Jin ;

Wood, Geryl ;

Masters, Seth L. ;

Richard, Katharina ;

Park, Grace ;

Smith, Brian J. ;

Kastner, Daniel L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :9982-9987

[4] IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells [J].

Kimura, Akihiro ;

Naka, Tetsuji ;

Kishimoto, Tadamitsu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (29) :12099-12104

[5] Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis [J].

Kitamura, K ;

Nakamoto, Y ;

Kaneko, S ;

Mukaida, N .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (06) :1111-1117

[6] Does immune activation continue during an attack-free period in familial Mediterranean fever? [J].

Musabak, U ;

Sengul, A ;

Oktenli, C ;

Pay, S ;

Yesilova, Z ;

Kenar, L ;

Sanisoglu, SY ;

Inal, A ;

Tuzun, A ;

Erdil, A ;

Bagci, S .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 138 (03) :526-533

[7] Type 1 T regulatory cells [J].

Roncarolo, MG ;

Bacchetta, R ;

Bordignon, C ;

Narula, S ;

Levings, MK .

IMMUNOLOGICAL REVIEWS, 2001, 182 :68-79

[8] Serum proinflammatory cytokines directing T helper 1 polarization in patients with familial Mediterranean fever [J].

Simsek, Ismail ;

Pay, Salih ;

Pekel, Aysel ;

Dinc, Ayhan ;

Musabak, Ugur ;

Erdem, Hakan ;

Sengul, Ali .

RHEUMATOLOGY INTERNATIONAL, 2007, 27 (09) :807-811

[9] CATERPILLERs, pyrin and hereditary immunological disorders [J].

Ting, JPY ;

Kastner, DL ;

Hoffman, HM .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (03) :183-195

[10] Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization [J].

Yu, JW ;

Wu, J ;

Zhang, Z ;

Datta, P ;

Ibrahimi, I ;

Taniguchi, S ;

Sagara, J ;

Fernandes-Alnemri, T ;

Alnemri, ES .

CELL DEATH AND DIFFERENTIATION, 2006, 13 (02) :236-249

← 1 →