Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation

被引：121

作者：

Banerjee, Samya ^{[2
]}

Prasad, Puja ^{[2
]}

Hussain, Akhtar ^{[2
]}

Khan, Imran ^{[1
]}

Kondaiah, Paturu ^{[1
]}

Chakravarty, Akhil R. ^{[2
]}

机构：

[1] Indian Inst Sci, Dept Mol Reprod Dev & Genet, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 62期

关键词：

DNA; DESIGN; ZN(II);

D O I：

10.1039/c2cc33576j

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC50 = 8.2 +/- 0.2 mu M and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex [VO(cur)(dppz)Cl] (IC50 = 3.3 +/- 0.4 mu M), while both are less toxic in the dark.

引用

收藏

页码：7702 / 7704

页数：3

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