Functional Mesoporous Silica Nanoparticles for Photothermal-Controlled Drug Delivery In Vivo

被引：273

作者：

Yan, Hong ^{[1
]}

Teh, Cathleen ^{[3
]}

Sreejith, Sivaramapanicker ^{[1
]}

Zhu, Liangliang ^{[1
]}

Kwok, Anna ^{[1
]}

Fang, Weiqin ^{[1
]}

Ma, Xing ^{[2
]}

Kim Truc Nguyen ^{[1
]}

Korzh, Vladimir ^{[3
]}

Zhao, Yanli ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore, Singapore

[3] Natl Univ Singapore, Inst Mol & Cell Biol, Lab Fish Dev Biol, Singapore 117548, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 33期

基金：

新加坡国家研究基金会;

关键词：

drug delivery; mesoporous silica nanoparticles; nanoparticles; photothermal switches; zebrafish; CONTROLLED-RELEASE; GUEST MOLECULES; LIGHT-DRIVEN; ROTAXANES; SURFACE;

D O I：

10.1002/anie.201203993

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Release me! A new class of photothermal-responsive [2]rotaxane-appended mesoporous silica nanoparticles (MSNPs) was developed. Remote-controlled movement of the α-cyclodextrin ring (green) upon trans-cis isomerization of the azobenzene axle (red) enables the loading and release of drugs on demand (see scheme). Curcumin-loaded MSNPs were shown to release curcumin into zebrafish larvae upon treatment with visible light or heat. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8373 / 8377

页数：5

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